Quickstart highlights
Dosing & reconstitution guide
This product is supplied ready to use; no reconstitution is required.
Protocol overview
Duration
Load to desired tone, then maintain
Route
Intranasal
Timing
Evening
Dosing protocol in research
| Phase | Dose | Frequency |
|---|---|---|
| Loading | 1–2 sprays | once daily |
| Maintenance | 1–2 sprays | 2–3× weekly |
Values as described in literature and research protocols; not dosing advice.
Storage instructions
- Store refrigerated (2–8 °C), upright and out of direct light.
- Avoid repeated freezing and thawing.
Important notes
- Dose per spray is less precise than injection.
How this works
Melanotan 2 nasal spray is a synthetic variant of the natural alpha-melanocyte-stimulating hormone. This version was developed as an alternative to injections, allowing the peptide to be absorbed through the blood vessels in the nasal cavity. Research focuses on the effectiveness of this administration method for stimulating skin pigmentation.
This peptide binds to melanocortin receptors, specifically MC1R through MC5R. Activation of MC1R stimulates eumelanin production in melanocytes. The nasal spray has lower bioavailability than injections, meaning a smaller portion of the active substance reaches the bloodstream. The half-life in the body is short, often less than two hours. Unlike Melanotan 1, Melanotan 2 is non-selective and also affects receptors involved in appetite and sexual arousal. Absorption through the nasal mucosa varies significantly between individuals.
Scientific research on the nasal form is limited compared to injectable variants. Past studies focused on treating erectile dysfunction and photoprotection in fair skin types. Melanotan 2 is not approved by the EMA or FDA for human use and is on the WADA prohibited list. Questions remain regarding the safety of long-term exposure of the nasal mucosa to this peptide. Most available data come from small-scale Phase 1 and 2 clinical trials.
Potential benefits & side effects
Effects described in research
- Tanning with less UV
- No injection required
Common side effects
- Nausea
- Nasal irritation
- Flushing
- Darkening of moles
Common reports in studies include nausea, flushing, and suppressed appetite. Users also report local nasal irritation and the development of new moles or hyperpigmentation. There is no data on long-term safety with chronic use.
Contraindications
- Pregnancy or breastfeeding
- Active or prior cancer
- Under 18 years of age
- Melanoma or atypical moles
Lifestyle factors
- Start with short, controlled UV exposure; burning is still possible.
- Use sunscreen and check moles regularly.
- Administration before bed reduces reported nausea.
Injection technique
- Blow your nose first and tilt your head slightly forward.
- Spray into one nostril while closing the other; inhale gently.
- Alternate nostrils each time.
Recommended source
Quality varies widely between suppliers. Look for an independent HPLC/MS lab report per batch, purity ≥ 98% and clear storage and shipping conditions.
As a reference we use the Melanotan neusspray from PeptideWinkel, which publishes lab reports per batch.
Ask a question about Melanotan neusspray
Answer based on our catalogue. Not medical advice — products are for research purposes only.
Log in to ask a question.
Frequently asked questions
How should this nasal spray be stored?
Store the spray in the refrigerator between 2 and 8 degrees Celsius after opening. Keep the bottle out of direct sunlight to prevent peptide degradation.
Is the absorption of a nasal spray the same as an injection?
No, nasal bioavailability is significantly lower. This means a higher dose is often required to reach blood levels comparable to a subcutaneous injection.
Why is Melanotan 2 classified as a research compound?
Because there is insufficient large-scale clinical evidence regarding its long-term safety and effectiveness. Health authorities have therefore not admitted it to the regulated medicine market.